ANTINOCICEPTIVE ACTION FOLLOWING MICRO-INJECTION OF METHIONINE-ENKEPHALIN IN THE NUCLEUS RAPHE MAGNUS OF THE RAT

被引：21

作者：

DICKENSON, AH ^{[1
]}

FARDIN, V ^{[1
]}

LEBARS, D ^{[1
]}

BESSON, JM ^{[1
]}

机构：

[1] INSERM,U161,UNITE RECH NEUROPHYSIOL PHARMACOL,2 RUE ALESIA,F-75014 PARIS,FRANCE

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96124-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The analgesic effect of the microinjection of low doses of methione-enkephalin (20 μg in 0.5 μl) into the caudal brain stem of the unrestrained rat was investigated by means of one vocalisation test. Immediate short duration significant increases in threshold (21%) were seen from sites in the nucleus raphé magnus (NRM). Delayed effects were seen from sites immediately adjacent to this nucleus; sites more lateral produced no significant effect. These results lend further support to the postulated role of NRM in antinociception. © 1979.

引用

页码：265 / 270

页数：6

共 13 条

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