AUTORADIOGRAPHIC STUDY ON DOPAMINE UPTAKE SITES AND THEIR CORRELATION WITH DOPAMINE LEVELS AND THEIR STRIATA FROM PATIENTS WITH PARKINSON DISEASE, ALZHEIMER-DISEASE, AND NEUROLOGICALLY NORMAL CONTROLS

被引：24

作者：

MIZUKAWA, K

MCGEER, EG

MCGEER, PL

机构：

[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,2255 WESBROOK MALL,VANCOUVER V6T 1Z3,BC,CANADA

[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DIS,VANCOUVER V6T 1Z3,BC,CANADA

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1993年 / 18卷 / 1-2期

关键词：

DOPAMINE UPTAKE; DOPAMINE LEVELS; PARKINSONISM; HUNTINGTON DISEASE; ALZHEIMER DISEASE; STRIATUM; MUSCARINIC; DOPAMINE RECEPTORS;

D O I：

10.1007/BF03160027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An autoradiographic study of labeled mazindol binding to presumed dopamine (DA) uptake sites in the striatum was done in 7 Parkinson (PD), 6 Alzheimer (AD), 1 Huntington disease (HD), and 4 neurologically normal cases. Large and significant decreases of specific binding were found in PD in both caudate (to 32% of control) and putamen (to 16%), with no significant effect in AD or HD. Nonspecific binding was a large proportion of total binding in all cases. In the 12 cases where both binding data and DA levels were available, they showed highly significant linear correlations in both caudate and putamen. Autoradiographic studies on D1, D2, and muscarinic binding sites in the PD, AD and control striata revealed no significant group differences.

引用

收藏

页码：133 / 144

页数：12

相关论文

共 21 条

[1] LOSS OF DOPAMINE UPTAKE SITES LABELED WITH [H-3] GBR-12935 IN ALZHEIMERS-DISEASE [J].

ALLARD, P ;

ALAFUZOFF, I ;

CARLSSON, A ;

ERIKSSON, K ;

ERICSON, E ;

GOTTFRIES, CG ;

MARCUSSON, JO .

EUROPEAN NEUROLOGY, 1990, 30 (04) :181-185

[2]

BERNHEIMER H, 1973, J NEUROL SCI, V20, P415, DOI 10.1016/0022-510X(73)90175-5

[3] EFFECTS OF TRANSIENT FOREBRAIN ISCHEMIA AND PARGYLINE ON EXTRACELLULAR CONCENTRATIONS OF DOPAMINE, SEROTONIN, AND THEIR METABOLITES IN THE RAT STRIATUM AS DETERMINED BY INVIVO MICRODIALYSIS [J].

DAMSMA, G ;

BOISVERT, DP ;

MUDRICK, LA ;

WENKSTERN, D ;

FIBIGER, HC .

JOURNAL OF NEUROCHEMISTRY, 1990, 54 (03) :801-808

[4] DISTRIBUTION OF CATECHOLAMINE UPTAKE SITES IN HUMAN BRAIN AS DETERMINED BY QUANTITATIVE [H-3] MAZINDOL AUTORADIOGRAPHY [J].

DONNAN, GA ;

KACZMARCZYK, SJ ;

PAXINOS, G ;

CHILCO, PJ ;

KALNINS, RM ;

WOODHOUSE, DG ;

MENDELSOHN, FAO .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 304 (03) :419-434

[5] CHARACTERIZATION OF SODIUM-DEPENDENT [H-3] GBR-12935 BINDING IN BRAIN - A RADIOLIGAND FOR SELECTIVE LABELING OF THE DOPAMINE TRANSPORT COMPLEX [J].

JANOWSKY, A ;

BERGER, P ;

VOCCI, F ;

LABARCA, R ;

SKOLNICK, P ;

PAUL, SM .

JOURNAL OF NEUROCHEMISTRY, 1986, 46 (04) :1272-1276

[6] [H-3] GBR-12935 BINDING TO THE DOPAMINE TRANSPORTER IS DECREASED IN THE CAUDATE-NUCLEUS IN PARKINSONS-DISEASE [J].

JANOWSKY, A ;

VOCCI, F ;

BERGER, P ;

ANGEL, I ;

ZELNIK, N ;

KLEINMAN, JE ;

SKOLNICK, P ;

PAUL, SM .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (02) :617-621

[7] SEVERE DEPLETION OF COCAINE RECOGNITION SITES ASSOCIATED WITH THE DOPAMINE TRANSPORTER IN PARKINSONS-DISEASED STRIATUM [J].

KAUFMAN, MJ ;

MADRAS, BK .

SYNAPSE, 1991, 9 (01) :43-49

[8] THE NIGROSTRIATAL DOPAMINERGIC SYSTEM ASSESSED INVIVO BY POSITRON EMISSION TOMOGRAPHY IN HEALTHY VOLUNTEER SUBJECTS AND PATIENTS WITH PARKINSONS-DISEASE [J].

LEENDERS, KL ;

SALMON, EP ;

TYRRELL, P ;

PERANI, D ;

BROOKS, DJ ;

SAGER, H ;

JONES, T ;

MARSDEN, CD ;

FRACKOWIAK, RSJ .

ARCHIVES OF NEUROLOGY, 1990, 47 (12) :1290-1298

[9] STRIOSOMAL ORGANIZATION OF CHOLINERGIC AND DOPAMINERGIC UPTAKE SITES AND CHOLINERGIC-M1 RECEPTORS IN THE ADULT HUMAN STRIATUM - A QUANTITATIVE RECEPTOR AUTORADIOGRAPHIC STUDY [J].

LOWENSTEIN, PR ;

JOYCE, JN ;

COYLE, JT ;

MARSHALL, JF .

BRAIN RESEARCH, 1990, 510 (01) :122-126

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265