ANGIOTENSIN-II STIMULATES PRODUCTION OF NITRIC-OXIDE IN GUINEA-PIG AIRWAYS VIA AT(1) RECEPTOR ACTIVATION

被引：9

作者：

KANAZAWA, H

KURIHARA, N

HIRATA, K

FUJIWARA, H

TAKEDA, T

机构：

[1] 1st Department of Internal Medicine, Osaka City University Medical School 1-5-7, Abenoku, Osaka, Asahi-machi

来源：

LIFE SCIENCES | 1995年 / 56卷 / 17期

关键词：

NITRIC OXIDE; ANGIOTENSIN II; BRONCHODILATION;

D O I：

10.1016/0024-3205(95)00094-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Angiotensin II (Ang II) and nitric oxide (NO) regulate a variety of physiological functions. In this study, we suggest that inhaled Ang II produces an initial bronchodilation apparently by stimulating NO production via AT(1) receptors. Also, we demonstrate that following the initial bronchodilation, Ang II causes bronchoconstriction in the guinea pig, also via AT(1) receptors. Both of the findings are important for our understanding of airway functions induced by Ang II.

引用

页码：1427 / 1431

页数：5

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