SYNTHESIS OF C-5'-SUBSTITUTED 2'-DEOXYNUCLEOSIDES

被引：9

作者：

NACRO, K ^{[1
]}

ESCUDIER, JM ^{[1
]}

BALTAS, M ^{[1
]}

GORRICHON, L ^{[1
]}

机构：

[1] UNIV TOULOUSE 3,CNRS,SYNTHESE & PHYSICOCHIM ORGAN LAB,F-31062 TOULOUSE,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期

关键词：

LACTONIZATION; 2'-DEOXYNUCLEOSIDES;

D O I：

10.1016/0040-4039(95)01645-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereocontrolled lactonisation of gamma,delta-epoxy beta-hydroxyesters provides, after reduction, 2-deoxysugars in pyrano or furano form. After appropriate protections of the hydroxyl functions, these sugars can be converted to various 2'-deoxynucleosides with different configuration of the sugar moiety and an extra functionalisation at C-5.

引用

页码：7867 / 7870

页数：4

共 22 条

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