MOLECULAR MESSENGERS OF OLFACTION

被引：97

作者：

RONNETT, GV

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 12期

关键词：

D O I：

10.1016/0166-2236(92)90104-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. A Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

引用

收藏

页码：508 / 513

页数：6

相关论文

共 87 条

[61] CROSS-TALK BETWEEN DIFFERENT INTRACELLULAR SIGNALING PATHWAYS IN THE RAT HIPPOCAMPUS [J].

PARENTI, M ;

CERESOLI, G ;

CONSOLO, S ;

GROPPETTI, A .

CELL BIOLOGY INTERNATIONAL REPORTS, 1989, 13 (12) :1177-1187

[62] IDENTIFICATION OF A SPECIFIC OLFACTORY RECEPTOR FOR 2-ISOBUTYL-3-METHOXYPYRAZINE [J].

PELOSI, P ;

BALDACCINI, NE ;

PISANELLI, AM .

BIOCHEMICAL JOURNAL, 1982, 201 (01) :245-248

[63] ISOLATION AND CHARACTERIZATION OF AN OLFACTORY RECEPTOR PROTEIN FOR ODORANT PYRAZINES [J].

PEVSNER, J ;

TRIFILETTI, RR ;

STRITTMATTER, SM ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :3050-3054

[64] ODORANT-BINDING PROTEIN - LOCALIZATION TO NASAL GLANDS AND SECRETIONS [J].

PEVSNER, J ;

SKLAR, PB ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4942-4946

[65] MOLECULAR-CLONING OF ODORANT-BINDING PROTEIN - MEMBER OF A LIGAND CARRIER FAMILY [J].

PEVSNER, J ;

REED, RR ;

FEINSTEIN, PG ;

SNYDER, SH .

SCIENCE, 1988, 241 (4863) :336-339

[66] ODORANT-BINDING PROTEIN AND ITS MESSENGER-RNA ARE LOCALIZED TO LATERAL NASAL GLAND IMPLYING A CARRIER FUNCTION [J].

PEVSNER, J ;

HWANG, PM ;

SKLAR, PB ;

VENABLE, JC ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2383-2387

[67] ODOR STIMULI TRIGGER INFLUX OF CALCIUM INTO OLFACTORY NEURONS OF THE CHANNEL CATFISH [J].

RESTREPO, D ;

MIYAMOTO, T ;

BRYANT, BP ;

TEETER, JH .

SCIENCE, 1990, 249 (4973) :1166-1168

[68] BIOCHEMICAL-STUDIES OF OLFACTION - BINDING-SPECIFICITY OF ODORANTS TO A CILIA PREPARATION FROM RAINBOW-TROUT OLFACTORY ROSETTES [J].

RHEIN, LD ;

CAGAN, RH .

JOURNAL OF NEUROCHEMISTRY, 1983, 41 (02) :569-577

[69] BIOCHEMICAL-STUDIES OF OLFACTION - ISOLATION, CHARACTERIZATION, AND ODORANT BINDING-ACTIVITY OF CILIA FROM RAINBOW-TROUT OLFACTORY ROSETTES .2. [J].

RHEIN, LD ;

CAGAN, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (08) :4412-4416

[70] ODORANT-SENSITIVE ADENYLATE-CYCLASE - RAPID, POTENT ACTIVATION AND DESENSITIZATION IN PRIMARY OLFACTORY NEURONAL CULTURES [J].

RONNETT, GV ;

PARFITT, DJ ;

HESTER, LD ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2366-2369

← 1 2 3 4 5 6 7 8 9 →