ECTOPIC (ILLEGITIMATE) TRANSCRIPTION - NEW POSSIBILITIES FOR THE ANALYSIS AND DIAGNOSIS OF HUMAN GENETIC-DISEASE

被引：33

作者：

COOPER, DN ^{[1
]}

BERG, LP ^{[1
]}

KAKKAR, VV ^{[1
]}

REISS, J ^{[1
]}

机构：

[1] INST HUMAN GENET,D-37079 GOTTINGEN,GERMANY

来源：

ANNALS OF MEDICINE | 1994年 / 26卷 / 01期

关键词：

ECTOPIC/ILLEGITIMATE TRANSCRIPTS; HUMAN GENETIC DISEASE;

D O I：

10.3109/07853899409147321

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

By means of the Polymerase Chain Reaction (PCR),'ectopic' or 'illegitimate' transcripts from any gene may be amplified from any tissue or cell type. RNA transcript analysis is therefore no longer dependent upon possession of the often inaccessible 'expressing' tissue. We review here the applications of ectopic transcript analysis to mutation detection and characterization, analysis of RNA splicing and the study of the genotype-phenotype relationship.

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页码：9 / 14

页数：6

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