NATURAL AND SYNTHETIC DERIVATIVES OF DISCORHABDIN-C, A CYTOTOXIC PIGMENT FROM THE NEW-ZEALAND SPONGE LATRUNCULIA CF BOCAGEI

被引：66

作者：

COPP, BR ^{[1
]}

FULTON, KF ^{[1
]}

PERRY, NB ^{[1
]}

BLUNT, JW ^{[1
]}

MUNRO, MHG ^{[1
]}

机构：

[1] UNIV CANTERBURY, DEPT CHEM, CHRISTCHURCH 1, NEW ZEALAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 26期

关键词：

D O I：

10.1021/jo00105a047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modification of the spiro-cyclohexadienone skeleton of discorhabdin C (3) led to a series of derivatives 6-11. The biological properties of this series were evaluated in a wide range of screens for selective cytotoxicity, antifungal, and antimicrobial properties. The structure and biological properties of a further discorhabdin, discorhabdin E (5), from a New Zealand sponge Latrunculia cf. bocagei are also presented.

引用

页码：8233 / 8238

页数：6