RAPID ESTIMATION OF OCTANOL-WATER PARTITION-COEFFICIENTS USING DEOXYCHOLATE MICELLES IN CAPILLARY ELECTROPHORESIS

被引：32

作者：

ADLARD, M

OKAFO, G

MEENAN, E

CAMILLERI, P

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

[2] UNIV WESTMINSTER,SCH BIOL & HLTH SCI,LONDON W1M 8JS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 21期

关键词：

D O I：

10.1039/C39950002241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Deoxycholic acid micelles have been used successfully in capillary electrophoresis to estimate the octanol-water partition coefficient (log P) of a number of drugs; the methodology developed is fast and is suitable for the determination of this physico-chemical parameter for neutral, basic and weakly acidic molecules with a variety of structures.

引用

页码：2241 / 2243

页数：3