GUANIDINIUM CATALYZED CONJUGATE ADDITION OF PYRROLIDINE TO UNSATURATED LACTONES

被引：61

作者：

ALCAZAR, V

MORAN, JR

DEMENDOZA, J

机构：

[1] UNIV AUTONOMA MADRID,DEPT QUIM ORGAN,E-28049 MADRID,SPAIN

[2] UNIV SALAMANCA,DEPT QUIM ORGAN,E-37008 SALAMANCA,SPAIN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 22期

关键词：

D O I：

10.1016/0040-4039(95)00647-U

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

More than a 8-fold reduction in half-life can be observed for conjugate additions of pyrrolidine to alpha,beta-unsaturated lactones in the presence of catalytic amounts (0.1 equiv.) of bicyclic chiral guanidinium salts 1, presumably by selective hydrogen-bond stabilization of the transition state.

引用

页码：3941 / 3944

页数：4

共 24 条

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