ETHANOL POTENTIATES THE GABA-A-ACTIVATED CL- CURRENT IN MOUSE HIPPOCAMPAL AND CORTICAL-NEURONS

被引：171

作者：

AGUAYO, LG

机构：

[1] Section of Electrophysiology, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 01期

关键词：

(Neuron); Cl[!sup]-[!/sup] currents; Cortex; Ethanol; GABA[!sub]A[!/sub] receptors; Hippocampus;

D O I：

10.1016/0014-2999(90)90349-B

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of ethanol (1-80 mM) on GABA-activated Cl- current (IGABA) were studied in cultured mammalian hippocampal and cortical neurons. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner (1-40 mM) in the majority of the cells studied. No higher degree of potentiation was found by increasing the concentration of ethanol to 80 mM. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons. © 1990.

引用

页码：127 / 130

页数：4

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