A PHOSPHOLIPID-BETA-2-GLYCOPROTEIN-I COMPLEX IS AN ANTIGEN FOR ANTICARDIOLIPIN ANTIBODIES OCCURRING IN AUTOIMMUNE-DISEASE BUT NOT WITH INFECTION

被引：274

作者：

HUNT, JE ^{[1
]}

MCNEIL, HP ^{[1
]}

MORGAN, GJ ^{[1
]}

CRAMERI, RM ^{[1
]}

KRILIS, SA ^{[1
]}

机构：

[1] UNIV NEW S WALES, ST GEORGE HOSP, SCH MED, KOGARAH, NSW 2217, AUSTRALIA

来源：

LUPUS | 1992年 / 1卷 / 02期

关键词：

ANTICARDIOLIPIN ANTIBODIES; BETA-2-GLYCOPROTEIN-I; THROMBOSIS;

D O I：

10.1177/096120339200100204

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anticardiolipin antibodies (aCL) purified from patients with autoimmune disease have recently been shown to interact with a phospholipid-binding plasma protein, beta-2-glycoprotein I (beta-2-GPI). The aim of this study was to determine whether aCL purified from patients with infection also interact with beta-2-GPI. aCL purified from 23 patients with malaria, infectious mononucleosis, tuberculosis, hepatitis A or syphilis did not require the presence of beta-2-GPI to bind cardiolipin (CL). In contrast, aCL were purified from 11 out of 12 patients with autoimmune disease that bound CL only in the presence of beta-2-GPI. Thrombotic complications appear to be associated with aCL occurring in autoimmune disease but not with aCL associated with infections. We postulate that this increased risk of thrombosis in the autoimmune group may be due to the presence of aCL that bind CL in association with beta-2-GPI, a plasma protein with anticoagulant activity.

引用

页码：75 / 81

页数：7

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