PHENOTYPIC VARIATION OF CARBOHYDRATE SURFACE-ANTIGENS AND THE PATHOGENESIS OF HAEMOPHILUS-INFLUENZAE INFECTIONS

被引：27

作者：

ROCHE, RJ ^{[1
]}

MOXON, ER ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP, INST MOLEC MED, DEPT PAEDIAT, MOLEC INFECT DIS GRP, OXFORD OX3 9DU, ENGLAND

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0966-842X(00)88959-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic variation of two major carbohydrate surface antigens of Haemophilus influenzae, the capsule and lipopolysaccharide, exemplifies some of the genetic mechanisms used by pathogenic bacteria in interacting with host micoenvironments. The ability to generate phenotypic variety at high frequency within clonal populations of microorganisms provides an adaptive mechanism to combat the polymorphisms and immune repertoires of the host.

引用

页码：304 / 309

页数：6

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