NEW ANTITUMOR SUBSTANCES, BE-12406A AND BE-12406B, PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：15

作者：

KOJIRI, K

ARAKAWA, H

SATOH, F

KAWAMURA, K

OKURA, A

SUDA, H

OKANISHI, M

机构：

[1] BANYU PHARMACEUT CO LTD,EXPLORATORY RES LABS,2-9-3 SHIMO MEGURO,MEGURO KU,TOKYO 153,JAPAN

[2] BANYU PHARMACEUT CO LTD,OKAZAKI RES LAB,OKAZAKI 444,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 10期

关键词：

D O I：

10.7164/antibiotics.44.1054

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Next antitumor substances, designated BE-12406A and BE-12406B, were isolated from the culture broth of a streptomycete, strain BA12406. The active principles were extracted from mycelium by methanol and successively purified by silica gel column chromatography and preparative TLC. BE-12406A and BE-12406B inhibited the growth of vincristine-resistant or doxorubicin-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line. In in vivo experiments, BE-12406A inhibited the growth of S-180 murine ascites tumor.

引用

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页码：1054 / 1060

页数：7

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