NEW ANTITUMOR SUBSTANCES, BE-12406A AND BE-12406B, PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引:15
作者
KOJIRI, K
ARAKAWA, H
SATOH, F
KAWAMURA, K
OKURA, A
SUDA, H
OKANISHI, M
机构
[1] BANYU PHARMACEUT CO LTD,EXPLORATORY RES LABS,2-9-3 SHIMO MEGURO,MEGURO KU,TOKYO 153,JAPAN
[2] BANYU PHARMACEUT CO LTD,OKAZAKI RES LAB,OKAZAKI 444,JAPAN
关键词
D O I
10.7164/antibiotics.44.1054
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Next antitumor substances, designated BE-12406A and BE-12406B, were isolated from the culture broth of a streptomycete, strain BA12406. The active principles were extracted from mycelium by methanol and successively purified by silica gel column chromatography and preparative TLC. BE-12406A and BE-12406B inhibited the growth of vincristine-resistant or doxorubicin-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line. In in vivo experiments, BE-12406A inhibited the growth of S-180 murine ascites tumor.
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收藏
页码:1054 / 1060
页数:7
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