BASE-PROMOTED INTRAMOLECULAR CYCLIZATION OF BROMOACETYLENIC ALCOHOL DERIVATIVES

被引：22

作者：

GRANDJEAN, D ^{[1
]}

PALE, P ^{[1
]}

CHUCHE, J ^{[1
]}

机构：

[1] UNIV REIMS,CNRS,CHIM ORGAN PHYS LAB,BP 347,F-51100 REIMS,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 34期

关键词：

BROMOACETYLENES; INTRAMOLECULAR CYCLIZATION; ALPHA-METHYLENE OXOLANES; BROMOMETHYLENE OXOLANES;

D O I：

10.1016/S0040-4039(00)61229-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Bromo-2,3-epoxy-4-pentyn-1-ol 6a, the corresponding esters 1a, 2a and the silyl protected form 5a could be intramolecularly cyclized under mildly basic conditions or with a catalytic amount of base. 1-Bromoethynyl-2-hydroxymethyl-cyclopropane 6b and its derivatives 2b and 5b could also be cyclized under the same conditions.

引用

页码：4905 / 4908

页数：4

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