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FUNCTIONAL EPIDERMAL GROWTH-FACTOR RECEPTOR LOCALIZES TO THE POSTACROSOMAL REGION OF HUMAN SPERMATOZOA

被引：21
作者：
DAMJANOV, I
SOLTER, D
KNOWLES, BB
机构：
[1] WISTAR INST, 3601 SPRUCE ST, PHILADELPHIA, PA 19104 USA
[2] MAX PLANCK INST IMMUNBIOL, W-7800 FREIBURG, GERMANY
[3] THOMAS JEFFERSON UNIV, DEPT PATHOL, PHILADELPHIA, PA 19107 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期
关键词：
D O I：
10.1006/bbrc.1993.1134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [γ-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization. © 1993 Academic Press, Inc.
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页码：901 / 906
页数：6
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