FUNCTIONAL EPIDERMAL GROWTH-FACTOR RECEPTOR LOCALIZES TO THE POSTACROSOMAL REGION OF HUMAN SPERMATOZOA

被引：21

作者：

DAMJANOV, I

SOLTER, D

KNOWLES, BB

机构：

[1] WISTAR INST, 3601 SPRUCE ST, PHILADELPHIA, PA 19104 USA

[2] MAX PLANCK INST IMMUNBIOL, W-7800 FREIBURG, GERMANY

[3] THOMAS JEFFERSON UNIV, DEPT PATHOL, PHILADELPHIA, PA 19107 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human epidermal growth factor receptor was detected immunohistochemically in the postacrosomal region of ejaculated human sperm and, when immunopurified and exposed to [γ-32P]ATP, was found to be autophosphorylated. Localization of an apparently enzymatically active epidermal growth factor receptor to spermatozoa suggests that epidermal growth factor receptor-ligand interactions may play a role in gamete physiology or in fertilization. © 1993 Academic Press, Inc.

引用

页码：901 / 906

页数：6

共 14 条

[11] DEVELOPMENTAL EXPRESSION OF PDGF, TGF-ALPHA, AND TGF-BETA GENES IN PREIMPLANTATION MOUSE EMBRYOS [J].