PLATELETS 3H 5-HT UPTAKE IN DESCENDANTS FROM ALCOHOLIC PATIENTS - A POTENTIAL RISK FACTOR FOR ALCOHOL DEPENDENCE

We studied platelet 3H-serotonin uptake in 32 former alcoholics, withdrawn for from 1 month to 22 years, in their descendants ( 21.7+/-1.6 years old, n=17; 10.9 0.7 years old; n=19), and in respective control groups, paired in age and sex. All of the alcoholics presented high 3H-serotonin uptake (Vmax=10.88+/-4.23 pmoles/10(8)pl/30sec.,vs. 0.93+/-0.15pmole/10(8)pl/30sec. Their descendants also showed high platelet serotonin uptake: 3.94+/-1.44 pmoles/10(8)pl/30sec., vs. 0.93+/-0.15 pmoles/10(8)pl/30sec. for adult descendants, and 5.99+/-2.23 vs. 0.84+/-0.15 pmole/10(8)pl/30 sec. for young descendants. All subjects were free of alcoholisation ( biological parameters studied were blood ethanol concentration, gamma glutamyl transferase and mean corpuscular volume), and dependence of former alcoholics was evaluate by using, a posteriori, the CAGE test. In descendants, 28% of the subjects have Vmax values higher than the highest of the control group. Alcohol, in vitro, (54 mM) did not affect serotonin uptake in any group. These results indicate that in descendants of alcoholics, platelet serotonin uptake is altered, without modification of sensitivity to ethanol. The genetic basis of alcohol dependence could be linked with the platelet serotonin transport.