ARSENIC-CADMIUM INTERACTION IN RATS

被引：28

作者：

DIAZBARRIGA, F ^{[1
]}

LLAMAS, E ^{[1
]}

MEJIA, JD ^{[1
]}

CARRIZALES, L ^{[1
]}

SANTOYO, ME ^{[1
]}

VEGAVEGA, L ^{[1
]}

YANEZ, L ^{[1
]}

机构：

[1] UNIV AUTONOMA SAN LUIS POTOSI,FAC MED,DEPT CIENCIAS MORFOL,CITOL EXPTL LAB,SAN LUIS POTOSI,MEXICO

来源：

TOXICOLOGY | 1990年 / 64卷 / 02期

关键词：

Air pollution; Arsenic; Cadmium; Co-exposure; Glutathione; Heavy metals;

D O I：

10.1016/0300-483X(90)90135-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Simultaneous exposure to cadmium and arsenic is highly probable in the urban area of San Luis Potosi, Mexico due to common localization of copper and zinc smelters. Therefore, in this work, rats were intraperitoneally exposed either to cadmium or arsenic alone, or simultaneously to both metals. The effects of these treatments on three different toxicological parameters were studied. Cadmium modified the LD50 of arsenic and conversely arsenic modified the LD50 for cadmium. At the histopathological level, arsenic appeared to protect against the cadmium effects, especially on tests. This protective effect seemed to be related to the glutathione levels found in this tissue: rats exposed to both arsenic and cadmium, presented glutathione values intermediate to those observed after exposure to either metal alone; arsenic had the highest value and cadmium the lowest. In liver, rats exposed to arsenic, cadmium or arsenic and cadmium, presented glutathione values below those in the saline group, with the lowest value corresponding to the arsenic cadmium treatment. The results appear to support the proposed interaction between arsenic and cadmium and coexposure to both metals seems to alter certain effects produced by either metal alone. © 1990.

引用

页码：191 / 203

页数：13

共 35 条

[11] INTERACTIONS AMONG LEAD, CADMIUM, AND ARSENIC IN RELATION TO PORPHYRIN EXCRETION PATTERNS [J].