DIFFERENTIAL-EFFECTS OF SPECIFIC OPIOID RECEPTOR AGONISTS ON RAT PUP ISOLATION CALLS

被引：86

作者：

CARDEN, SE ^{[1
]}

BARR, GA ^{[1
]}

HOFER, MA ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1991年 / 62卷 / 01期

关键词：

ULTRASONIC VOCALIZATION; MATERNAL SEPARATION; ISOLATION DISTRESS; DEVELOPMENT; OPIATE AGONIST; OPIOID RECEPTORS-MU; RECEPTOR-DELTA; RECEPTOR-KAPPA;

D O I：

10.1016/0165-3806(91)90185-L

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The possibility was investigated that specific opioid receptor types might selectively alter the production of isolation-induced ultrasonic vocalizations. Intracisternal injections of mu, delta and kappa-opioid receptor agonists were administered to isolated 10-day-old rat pups. The mu-receptor agonist [D-Ala2-NMe-Phe4-Gly-ol]-enkephalin (DAMGO) and delta-receptor agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) both reduced the rate of isolation-induced ultrasonic calling in the absence of sedation. The kappa-receptor agonist U50,488 had the opposite effect, significantly raising the rate of vocalization. Fourteen-day-old pups, with a larger delta-receptor population, showed a greater sensitivity to DPDPE than was seen in the younger animals.

引用

页码：17 / 22

页数：6