THE POWER OF THE N-TEST OF HAPLOTYPE CONCORDANCE

被引：5

作者：

GREEN, JR

SHAH, S

机构：

[1] Statistics and Computational Mathematics Department, Liverpool University, Liverpool, L69 3BX

来源：

ANNALS OF HUMAN GENETICS | 1992年 / 56卷

关键词：

D O I：

10.1111/j.1469-1809.1992.tb01161.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The N-test of haplotype concordance among siblings affected by some disease under investigation is used to decide whether there is a disease susceptibility gene linked to a marker locus or chromosomal region. The use of this test and appropriate modifications of it is briefly reviewed. The power of the ordinary N-test is then derived as a function of several parameters. The sample size needed to attain a given power is then derived. Some of the parameters are specified and the required sample sizes are given in tables for different values of the main unknown parameters.

引用

页码：331 / 338

页数：8

共 11 条

[1]

DEVRIES RRP, 1976, LANCET, V2, P1328

[2] THE DISTRIBUTIONS OF N AND F - MEASURES OF HLA HAPLOTYPE CONCORDANCE [J].