HIGH-RESOLUTION LOCALIZATION OF RECOMBINATION HOT-SPOTS USING SPERM TYPING

被引：68

作者：

HUBERT, R

MACDONALD, M

GUSELLA, J

ARNHEIM, N

机构：

[1] UNIV SO CALIF,PROGRAM MOLEC BIOL,LOS ANGELES,CA 90089

[2] MASSACHUSETTS GEN HOSP,NEUROGENET PROGRAM,BOSTON,MA 02114

来源：

NATURE GENETICS | 1994年 / 7卷 / 03期

关键词：

D O I：

10.1038/ng0794-420

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have applied sperm DNA typing to determine the distribution of crossover events within a one megabase region of the short arm of human chromosome 4 near the locus for Huntington disease. A total of 29 recombinants were detected among 602 sperm typed after whole genome amplification. These recombinants were typed for seven polymorphic markers. The 280 kilobase D4S10-D4S126 interval was found to undergo recombination at a 6-9-fold greater rate per unit of physical distance than the adjacent 720 kb D4S126-D4S127 interval. Sperm typing has the potential to dissect mammalian recombination hot spots to the point where DNA sequence analysis may reveal the molecular basis for hyperrecombination.

引用

页码：420 / 424

页数：5

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