ACTIVITY OF URETHANE IN RAT AND MOUSE MICRONUCLEUS TESTS AFTER ORAL-ADMINISTRATION

被引：10

作者：

WESTMORELAND, C ^{[1
]}

PLUMSTEAD, M ^{[1
]}

GATEHOUSE, D ^{[1
]}

机构：

[1] GLAXO RES GRP LTD,DEPT GENET REPRODUCT TOXICOL,PK RD,WARE SG12 0DP,HERTS,ENGLAND

来源：

MUTATION RESEARCH | 1991年 / 262卷 / 04期

关键词：

URETHANE; ORAL ADMINISTRATION; MICRONUCLEUS TEST; (RAT); (MOUSE);

D O I：

10.1016/0165-7992(91)90091-H

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Urethane is readily detectable as an in vivo clastogen in the micronucleus test after oral administration to both rats and mice. Mice appear to be the more sensitive species. Positive results were obtained irrespective of the strain (CD1, CRH) or dosing regimen (single, triple-dose) used.

引用

页码：247 / 251

页数：5