GALACTOSE-IMINES IN THE STAUDINGER REACTION

被引：33

作者：

GEORG, GI ^{[1
]}

AKGUN, E ^{[1
]}

MASHAVA, PM ^{[1
]}

MILSTEAD, M ^{[1
]}

PING, H ^{[1
]}

WU, ZJ ^{[1
]}

VANDERVELDE, D ^{[1
]}

TAKUSAGAWA, F ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 16期

关键词：

STAUDINGER REACTION; ASYMMETRIC SYNTHESIS; BETA-LACTAMS; ALPHA-HYDROXY-BETA-AMINO ACIDS;

D O I：

10.1016/0040-4039(92)88153-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Staudinger reaction of imines 1 and 2 derived from galactose with a variety of acid chlorides resulted in the formation of two beta-lactams with cis configuration, typically in 60:40 ratio and in good yields. The beta-lactams were separated and the absolute stereochemistry of the diastereoisomers was determined by single crystal X-ray analysis and correlation of their H-1-NMR data.

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页码：2111 / 2114

页数：4

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