4-HYDROXYHEXENAL - A LIPID-PEROXIDATION PRODUCT DERIVED FROM OXIDIZED DOCOSAHEXAENOIC ACID

被引：106

作者：

VANKUIJK, FJGM

HOLTE, LL

DRATZ, EA

机构：

[1] Chemistry Department, Montana State University, Bozeman, MT

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1043卷 / 01期

关键词：

4-Hydroxyhexenal; 4-Hydroxynonenal; Docosahexaenoic acid; Lipid peroxidation;

D O I：

10.1016/0005-2760(90)90118-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues. © 1990.

引用

收藏

页码：116 / 118

页数：3

相关论文

共 18 条

[1] IDENTIFICATION OF 4-HYDROXYNONEAL AS A CYTO-TOXIC PRODUCT ORIGINATING FROM THE PEROXIDATION OF LIVER MICROSOMAL LIPIDS [J].

BENEDETTI, A ;

COMPORTI, M ;

ESTERBAUER, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 620 (02) :281-296

[2] CHEMOTACTIC ACTIVITY OF THE LIPID-PEROXIDATION PRODUCT 4-HYDROXYNONENAL AND HOMOLOGOUS HYDROXYALKENALS [J].

CURZIO, M ;

ESTERBAUER, H ;

DIMAURO, C ;

CECCHINI, G ;

DIANZANI, MU .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1986, 367 (04) :321-329

[3]

ECKL P, 1989, ADV BIOSCI, V76, P141

[4] STUDIES ON THE MECHANISM OF FORMATION OF 4-HYDROXYNONENAL DURING MICROSOMAL LIPID-PEROXIDATION [J].

ESTERBAUER, H ;

BENEDETTI, A ;

LANG, J ;

FULCERI, R ;

FAULER, G ;

COMPORTI, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 876 (01) :154-166

[5] SEPARATION AND CHARACTERIZATION OF THE ALDEHYDIC PRODUCTS OF LIPID-PEROXIDATION STIMULATED BY ADP-FE2+ IN RAT-LIVER MICROSOMES [J].

ESTERBAUER, H ;

CHEESEMAN, KH ;

DIANZANI, MU ;

POLI, G ;

SLATER, TF .

BIOCHEMICAL JOURNAL, 1982, 208 (01) :129-140

[6]

ESTERBAUER H, 1986, FREE RADICALS LIVER, P29

[7]

Esterbauer H., 1982, FREE RADICAL LIPID P, P101

[8] VOLATILE LIPID OXIDATION-PRODUCTS [J].

FRANKEL, EN .

PROGRESS IN LIPID RESEARCH, 1983, 22 (01) :1-33

[9] ANALYSIS OF AUTOXIDIZED FATS BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY .9. HOMOLYTIC VS HETEROLYTIC CLEAVAGE OF PRIMARY AND SECONDARY OXIDATION-PRODUCTS [J].

FRANKEL, EN ;

NEFF, WE ;

SELKE, E .

LIPIDS, 1984, 19 (10) :790-800

[10] RAPID AUTOXIDATION OF FISH OIL IN DIETS WITHOUT ADDED ANTIOXIDANTS [J].

FRITSCHE, KL ;

JOHNSTON, PV .

JOURNAL OF NUTRITION, 1988, 118 (04) :425-426