FACTOR REQUIRED FOR MAMMALIAN SPLICEOSOME ASSEMBLY IS LOCALIZED TO DISCRETE REGIONS IN THE NUCLEUS

被引：659

作者：

FU, XD

MANIATIS, T

机构：

[1] Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138

来源：

NATURE | 1990年 / 343卷 / 6257期

关键词：

D O I：

10.1038/343437a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus. © 1990 Nature Publishing Group.

引用

页码：437 / 441

页数：5

共 42 条

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