MECHANISM OF PROTEIN FOLDING

被引：18

作者：

PTITSYN, OB

FINKELSTEIN, AV

机构：

[1] Institute of Protein Research, Academy of Sciences of the U.S.S.R, Moscow Region

来源：

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY | 1979年 / 16卷 / 03期

关键词：

D O I：

10.1002/qua.560160302

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The first stage of protein self‐organization—the formation of a fluctuating secondary structure in the unfolded protein chain—is considered. The stereochemical theory is presented enabling one to calculate helix‐coil and β‐structure‐coil equilibrium constants. It is shown that the most probable localization of fluctuating α‐ and β‐structure in the unfolded protein chain corresponds to the native localization of these structures. The formation of large α‐ and β‐structural blocks is observed, each of them including several native α‐helices or β‐strands. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：407 / 418

页数：12

共 57 条

[1]

ALEXANIAN VI, 1974, MOL BIOL, V8, P182

[2] HELIX-COIL STABILITY-CONSTANTS FOR NATURALLY OCCURRING AMINO-ACIDS IN WATER .6. LEUCINE PARAMETERS FROM RANDOM POLY(HYDROXYPROPYLGLUTAMINE-CO-L-LEUCINE) AND POLY(HYDROXYBUTYLGLUTAMINE-CO-L-LEUCINE) [J].