CYTOCHROME-P450CAM - CRYSTALLOGRAPHY, OXYGEN ACTIVATION, AND ELECTRON-TRANSFER

被引：150

作者：

POULOS, TL

RAAG, R

机构：

[1] MARYLAND BIOTECHNOL INST,CTR ADV RES BIOTECHNOL,ROCKVILLE,MD 20850

[2] UNIV MARYLAND,DEPT CHEM BIOCHEM,COLLEGE PK,MD 20742

来源：

FASEB JOURNAL | 1992年 / 6卷 / 02期

关键词：

P450CAM; OXYGEN ACTIVATION; ACID CATALYSIS; MUTAGENESIS; ELECTRON TRANSFER;

D O I：

10.1096/fasebj.6.2.1537455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several crystal structures of various substrate and inhibited complexes of the camphor monoxygenase, cytochrome P450cam from Pseudomonas putida, are now available. These structures, together with mutagenesis, biochemical, and biophysical studies, have allowed for a detailed penetration into the problem of how P450s activate molecular oxygen, control stereoselectivity, and transfer electrons. This review will provide a of the crystallographic work in light of what these structures have taught us about P450 function.

引用

页码：674 / 679

页数：6

共 31 条

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