SYMPATHETIC THYROIDAL VASOCONSTRICTION IS NOT BLOCKED BY A NEUROPEPTIDE-Y ANTAGONIST OR ANTISERUM

被引：9

作者：

DEY, M ^{[1
]}

MICHALKIEWICZ, M ^{[1
]}

HUFFMAN, L ^{[1
]}

HEDGE, GA ^{[1
]}

机构：

[1] W VIRGINIA UNIV,MED CTR,SCH MED,HLTH SCI CTR,SCH MED,2267 HLTH SCI S,MORGANTOWN,WV 26506

来源：

PEPTIDES | 1993年 / 14卷 / 06期

基金：

美国国家科学基金会;

关键词：

NOREPINEPHRINE; LASER DOPPLER BLOOD FLOWMETRY; CERVICAL SYMPATHETIC TRUNK;

D O I：

10.1016/0196-9781(93)90173-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sympathetic nerve fibers to thyroid blood vessels contain both norepinephrine (NE) and neuropeptide Y (NPY). To assess the involvement of endogenous NPY in the sympathetic neural control of thyroid blood flow, appropriate doses of a selective NPY antagonist, alpha-trinositol, and an NPY antiserum (NPY-AS) were used during cervical sympathetic trunk stimulation in anesthetized rats. During all experiments, thyroid blood flow was continuously monitored by laser Doppler blood flowmetry. Neither a-trinositol nor NPY-AS blocked the thyroidal vasoconstriction evoked by either the first or second stimulation of the cervical sympathetic trunks. Our results suggest that NPY is not involved either directly or indirectly during acute sympathetic vasoconstriction in the rat thyroid gland.

引用

页码：1179 / 1186

页数：8

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