OLIGONUCLEOTIDES HAVING COVALENTLY-LINKED ANTHRACENE AT SPECIFIC SUGAR RESIDUE - DIFFERENTIAL BINDING TO DNA AND RNA AND FLUORESCENCE PROPERTIES

被引：31

作者：

YAMANA, K

AOTA, R

NAKANO, H

机构：

[1] Department of Applied Chemistry, Himeji Institute of Technology, Himeji, Hyogo, 671-22

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 46期

关键词：

D O I：

10.1016/0040-4039(95)01707-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligonucleotide 15 -mers containing 2-anthracenylmethyl groups at specific sugar residues have been synthesized from the 2'-anthracene-modified uridine. The modified oligonucleotides bind to both the complementary DNA and RNA segments. The induced CD at around 375 nm due to the anthracene chromophore was seen only for the anthracene-modified duplexes with DNA but not for those with RNA, which is in good agreement with the modification-induced stability of the duplexes. The oligonucleotide with anthracene at the specified sugar residue exhibits enhanced fluorescence upon binding to the complementary RNA segment.

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页码：8427 / 8430

页数：4

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