ADHESION MOLECULES - A NEW TARGET FOR IMMUNOLIPOSOME-MEDIATED DRUG-DELIVERY

被引:99
作者
BLOEMEN, PGM
HENRICKS, PAJ
VANBLOOIS, L
VANDENTWEEL, MC
BLOEM, AC
NIJKAMP, FP
CROMMELIN, DJA
STORM, G
机构
[1] UNIV UTRECHT, INST PHARMACEUT SCI, DEPT PHARMACEUT, 3508 TB UTRECHT, NETHERLANDS
[2] ACAD HOSP UTRECHT, DEPT IMMUNOL, 3584 CX UTRECHT, NETHERLANDS
来源
FEBS LETTERS | 1995年 / 357卷 / 02期
关键词
IMMUNOLIPOSOME; MONOCLONAL ANTIBODY; ICAM-1; EPITHELIUM; ENDOTHELIUM;
D O I
10.1016/0014-5793(94)01350-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The anti-ICAM-1 monoclonal antibody F10.2 was conjugated to liposomes to target to cells expressing the cell adhesion molecule ICAM-1. We demonstrate that F10.2 immunoliposomes bind to human bronchial epithelial cells (BEAS-2B) and human umbilical vein endothelial cells (HUVEC) in a specific, dose- and time-dependent manner. It appears that the degree of ICAM-1 expression is the limiting factor in the degree of immunoliposome binding to the cells. These results are a first step in the strategy for specific drug delivery to target sites characterised by increased expression of adhesion molecules.
引用
收藏
页码:140 / 144
页数:5
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