CHROMOSOME-SPECIFIC MICROSATELLITE SETS FOR FLUORESCENCE-BASED, SEMIAUTOMATED GENOME MAPPING

被引：307

作者：

REED, PW

DAVIES, JL

COPEMAN, JB

BENNETT, ST

PALMER, SM

PRITCHARD, LE

GOUGH, SCL

KAWAGUCHI, Y

CORDELL, HJ

BALFOUR, KM

JENKINS, SC

POWELL, EE

VIGNAL, A

TODD, JA

机构：

[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG,OXFORD OX3 9DU,ENGLAND

[2] UNIV OXFORD,NUFFIELD ORTHOPAED CTR,WELLCOME TRUST CTR HUMAN GENET,OXFORD OX3 7LD,ENGLAND

[3] GENETHON,F-91000 EVRY,FRANCE

来源：

NATURE GENETICS | 1994年 / 7卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng0794-390

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To facilitate large-scale genetic mapping of the human genome, we have developed chromosome-specific sets of microsatellite marker loci suitable for use with a fluorescence-based automated DNA fragment analyser. We present 254 dinucleotide repeat marker loci (80% from the Genethon genetic linkage map) arranged into 39 sets, covering all 22 autosomes and the X chromosome. The average distance between adjacent markers is 13 centiMorgans, and less than 4% of the genome lies more than 20 cM from the nearest marker. Each set of microsatellites consists of up to nine marker loci, with allele size ranges that do not overlap. We selected marker loci on the basis of their reliability in the polymerase chain reaction, polymorphism content, map position and the accuracy with which alleles can be scored automatically by the Genotyper(TM) program.

引用

页码：390 / 395

页数：6

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