GENETIC-MARKERS - ASSOCIATION STUDY IN MIGRAINE

被引：18

作者：

PARDO, J ^{[1
]}

CARRACEDO, A ^{[1
]}

MUNOZ, I ^{[1
]}

CASTILLO, J ^{[1
]}

LEMA, M ^{[1
]}

NOYA, M ^{[1
]}

机构：

[1] FAC MED SANTIAGO DE COMPOSTELA,INST LEGAL MED,SANTIAGO,SPAIN

来源：

CEPHALALGIA | 1995年 / 15卷 / 03期

关键词：

D O I：

10.1046/j.1468-2982.1995.015003200.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Eleven genetic markers were typed in 112 unrelated patients with migraine (50 with aura, 62 without aura) and compared with a random sample of healthy individuals. No significant differences were found for the ABO and Rh systems, acid phosphatase 1, phosphoglucomutase I, adenosine deaminase, haptoglobin, transferrin, alpha-l-antitrypsin, and D1S80. Strong associations between the group of patients with migraine and group-specific component GC IF-IF and esterase-D ESD 2-2 phenotypes were observed. These associations raise the possibility that a molecular genetic factor for migraine may exist in or near the Group Component (chromosome 4) and Esterase D (chromosome 13) loci, and represent a first comprehensive step in the eventual localization and isolation of the migraine genes.

引用

页码：200 / 204

页数：5