TOXICITY OF THE CYSTEINE-S-CONJUGATES AND MERCAPTURIC ACIDS OF 4 STRUCTURALLY RELATED DIFLUOROETHYLENES IN ISOLATED PROXIMAL TUBULAR CELLS FROM RAT-KIDNEY - UPTAKE OF THE CONJUGATES AND ACTIVATION TO TOXIC METABOLITES

被引：50

作者：

BOOGAARD, PJ ^{[1
]}

COMMANDEUR, JNM ^{[1
]}

MULDER, GJ ^{[1
]}

VERMEULEN, NPE ^{[1
]}

NAGELKERKE, JF ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM,DEPT PHARMACOCHEM MOLEC TOXICOL,1081 HV AMSTERDAM,NETHERLANDS

来源：

BIOCHEMICAL PHARMACOLOGY | 1989年 / 38卷 / 21期

关键词：

D O I：

10.1016/0006-2952(89)90579-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

收藏

页码：3731 / 3741

页数：11

相关论文

共 28 条

[1] CELLULAR EFFECTS OF REACTIVE INTERMEDIATES - NEPHROTOXICITY OF S-CONJUGATES OF AMINO-ACIDS
ANDERS, MW
ELFARRA, AA
LASH, LH
[J]. ARCHIVES OF TOXICOLOGY, 1987, 60 (1-3) : 103 - 108
[2] BAKKE JE, 1981, DRUG METAB DISPOS, V9, P525
[3] PROBENECID-INDUCED PROTECTION AGAINST ACUTE HEXACHLORO-1,3-BUTADIENE AND METHYL MERCURY TOXICITY TO THE MOUSE KIDNEY
BAN, M
DECEAURRIZ, J
[J]. TOXICOLOGY LETTERS, 1988, 40 (01) : 71 - 76
[4] BOOGAARD PJ, IN PRESS TOXICOL APP
[5] BOOGAARD PJ, 1989, NEPHROTOXICITY EXTRA, P337
[6] NEPHROTOXICITY OF MERCAPTURIC ACIDS OF 3 STRUCTURALLY RELATED 2,2-DIFLUOROETHYLENES IN THE RAT - INDICATIONS FOR DIFFERENT BIOACTIVATION MECHANISMS
COMMANDEUR, JNM
BRAKENHOFF, JPG
DEKANTER, FJJ
VERMEULEN, NPE
[J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (23) : 4495 - 4504
[7] NEPHROTOXICITY AND HEPATOTOXICITY OF 1,1-DICHLORO-2,2-DIFLUOROETHYLENE IN THE RAT - INDICATIONS FOR DIFFERENTIAL MECHANISMS OF BIOACTIVATION
COMMANDEUR, JNM
OOSTENDORP, RAJ
SCHOOFS, PR
XU, B
VERMEULEN, NPE
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (24) : 4229 - 4237
[8] COMMANDEUR JNM, UNPUB BIOACTIVATION
[9] BIOACTIVATION MECHANISM OF THE CYTOTOXIC AND NEPHROTOXIC S-CONJUGATE S-(2-CHLORO-1,1,2-TRIFLUOROETHYL)-L-CYSTEINE
DEKANT, W
LASH, LH
ANDERS, MW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) : 7443 - 7447
[10] DOHN DR, 1985, J PHARMACOL EXP THER, V235, P851