HISTOCHEMICAL COMPARISON OF FOCAL LOSSES OF RNASE AND ATPASE ACTIVITIES IN PRENEOPLASTIC RAT LIVERS

被引：22

作者：

DAOUST, R ^{[1
]}

机构：

[1] UNIV MONTREAL,DEPT ANAT,MONTREAL H3C 3J7,QUEBEC,CANADA

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 1979年 / 27卷 / 02期

关键词：

D O I：

10.1177/27.2.156207

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To better assess the significance of enzyme-deficient foci as putative premalignant lesions, parallel histochemical analyses of RNase and ATPase activities were carried out in serial sections of livers from rats fed 4-dimethylaminoazobenzene. The results showed that focal losses of RNase and canalicular ATPase activities occur simultaneously in congruent areas of liver parenchyma at early stages of carcinogenesis. Such foci presumably represent altered cells capable of progressing to neoplasia since the changes observed in this new cell population persist in developing tumors.

引用

页码：653 / 656

页数：4