NEW AMINO SUGAR ANALOGS ARE INCORPORATED AT DIFFERENT RATES INTO GLYCOPROTEINS OF MOUSE ORGANS

被引：27

作者：

KAYSER, H ^{[1
]}

ATS, C ^{[1
]}

LEHMANN, J ^{[1
]}

REUTTER, W ^{[1
]}

机构：

[1] UNIV FREIBURG,INST ORGAN CHEM & BIOCHEM,D-79104 FREIBURG,GERMANY

来源：

EXPERIENTIA | 1993年 / 49卷 / 10期

关键词：

AMINO SUGAR ANALOGS; LIVER; INTESTINE; GLYCOPROTEINS;

D O I：

10.1007/BF01952603

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Different radiolabelled N-acyl-derivatives of D-glucosamine were synthesized using D-glucosamine and the respective carbonic acid anhydride. Metabolism of these sugar analogues could be shown in vitro as well as in vivo. After the intraperitoneal administration of these radiolabelled N-acyl-D-glucosamines to mice, their rate of incorporation into glycoproteins of different organs was found to increase markedly with the length of the N-acyl side chain. Highest incorporation was measured in the whole intestine using N-pentanoyl-D-glucosamine as label.

引用

页码：885 / 887

页数：3

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