SYNTHESIS OF N-ACYL-2-AMINO-2-DEOXY-[1-C-14]-GLUCOSES AS PRECURSORS FOR THE BIOSYNTHESIS OF NOVEL N-ACYL-NEURAMINIC ACIDS

被引：3

作者：

KAYSER, H ^{[1
]}

ZEITLER, R ^{[1
]}

HOPPE, B ^{[1
]}

REUTTER, W ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST MOLEK BIOL & BIOCHEM,ARNIMALLEE 22,W-1000 BERLIN 33,GERMANY

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 09期

关键词：

N-ACYL-2-AMINO-2-DEOXY-[1-C-14]-D-GLUCOSES; GLYCOCONJUGATES; SIALIC ACID;

D O I：

10.1002/jlcr.2580310910

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

N-Propanoyl-, N-butanoyl-, N-pentanoyl-, N-hexanoyl-, N-heptanoyl- and N-crotonoyl-[1-C-14]-D-glucosamine were synthesized from [1-C-14]-D-glucosamine and their respective carbonic acid anhydrides as precursors for the biosynthesis of the corresponding N-acyl neuraminic acids. The N-acyl-glucosamines are phosphorylated to their respective phosphate by N-acetyl-glucosamine kinase in a rat liver homogenate. These precursors may become valuable tools to investigate the biological role of the N-acyl side chain of N-acyl-glucosamines and N-acyl neuraminic acids which are components of glycoconjugates.

引用

页码：711 / 715

页数：5

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