NEURONAL SIGNALING OF INFORMATION IMPORTANT TO VISUAL RECOGNITION MEMORY IN RAT RHINAL AND NEIGHBORING CORTICES

被引:165
作者
ZHU, XO
BROWN, MW
AGGLETON, JP
机构
[1] UNIV BRISTOL,DEPT ANAT,BRISTOL BS8 1TD,AVON,ENGLAND
[2] UNIV WALES COLL CARDIFF,SCH PSYCHOL,CARDIFF CF1 3YG,S GLAM,WALES
关键词
SINGLE-UNIT RECORDING; WORKING AND PRIMING MEMORY; MEDIAL TEMPORAL LOBE; INFERIOR TEMPORAL CORTEX; HIPPOCAMPUS; VISUAL CORTEX;
D O I
10.1111/j.1460-9568.1995.tb00679.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study was conducted to discover whether the rat cortex contains neurons that signal information concerning the previous occurrence of stimuli, as has been found in the primate. Recordings of the activity of 396 single neurons were made while unanaesthetized rats were shown objects. The effects on neuronal responsiveness of stimulus repetition and of the relative familiarity of the stimuli were sought. The areas sampled were the rhinal (entorhinal and perirhinal) cortex, area TE of the temporal cortex, the lateral occipital cortex and the hippocampal formation. The response to the first presentations of objects was significantly different from that to their second presentations for 63 (34%) of the 185 responsive neurons; for 39 of the neurons the response was smaller when the stimulus was repeated, whereas for 24 it was larger. The incidence of decremental responses was higher in the non-hippocampal cortex than in the hippocampal formation, while the incidence of incremental responses was higher in the hippocampal formation than other cortical areas. The response to unfamiliar objects was significantly different from that to highly familiar objects for 15 (22%) of 67 responsive neurons so tested; for 12 of the neurons the response was smaller when the stimulus was repeated, and for three it was larger; most of these neurons were found in area TE. The responses of ten familiarity neurons varied significantly with the relative familiarity of the stimuli but not with stimulus repetition; the responses of seven recency neurons varied significantly upon stimulus repetition but not with the relative familiarity of the stimuli. Thus information concerning stimulus repetition and familiarity is separably encoded at the single neuron level in the rat cortex. The results demonstrate that in the rat cortex as in the monkey cortex there are neurons that signal information concerning the prior occurrence of stimuli; such information is of importance to recognition memory, working memory and priming memory,
引用
收藏
页码:753 / 765
页数:13
相关论文
共 58 条
  • [41] Rolls E.T., Cahusac P.M.B., Feigenbaum J.D., Miyashita Y., Responses of single neurons in the hippocampus of the macaque related to recognition memory, Exp. Brain Res., 93, pp. 299-306, (1993)
  • [42] Rolls E.T., Perrett D.I., Caan A.W., Wilson F.A.W., Neuronal responses related to visual recognition, Brain, 105, pp. 611-646, (1982)
  • [43] Shaw C., Aggleton J.P., The effects of fornix and medial prefrontal lesions on delayed non‐matching‐to‐sample by rats, Behav. Brain Res., 54, pp. 91-102, (1993)
  • [44] Sobotka S., Ringo J.L., Investigations of long term recognition and association memory in unit responses from inferotemporal cortex, Exp. Brain Res., 96, pp. 28-38, (1993)
  • [45] Squire L.R., Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans, Psychol. Rev., 99, pp. 195-231, (1992)
  • [46] Steele K., Rawlins J.N.P., The effects of hippocampectomy on performance by rats of a running recognition task using lists of non‐spatial items, Behav. Brain Res., 54, pp. 1-10, (1993)
  • [47] Suzuki H., Azuma M., A glass‐insulated ‘Elgiloy’ microelectrode for recording unit activity in chronic monkey experiments, Electroencephalogr. Clin. Neurophysiol., 41, pp. 93-95, (1976)
  • [48] Suzuki W.A., Zola-Morgan S., Squire L.R., Amaral D.G., Lesions of the perirhinal and parahippocampal cortices in the monkey produce long‐lasting memory impairment in the visual and tactual modalities, J. Neurosci., 13, pp. 2430-2451, (1993)
  • [49] Taube J.S., Muller R.U., Ranck J.B., Head‐direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis, J. Neurosci., 10, pp. 420-435, (1990)
  • [50] Thompson R.F., Spencer W.A., Habituation: a model phenomenon for the study of neuronal substrates of behaviour, Psychol. Rev., 73, pp. 16-43, (1966)