NEW SYNTHESES OF ARYLPHOSPHINIC ACIDS FROM THE REACTION OF ETHYL DIETHOXYMETHYLPHOSPHINATE WITH ARYL BROMIDES AND PHENOLS

被引：33

作者：

BENNETT, SNL ^{[1
]}

HALL, RG ^{[1
]}

机构：

[1] CIBA GEIGY PLC,CENT RES LABS,MACCLESFIELD SK10 2NX,CHESHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 09期

关键词：

D O I：

10.1039/p19950001145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemistry of the hypophosphorous acid synthon, ethyl diethoxymethylphosphinate 1 has been further developed to afford efficient new routes to arylphosphinic acids 6 and 2-hydroxyphenylphosphinic acids 10. In one approach, a palladium(0) catalysed P-H insertion has been used; the second approach utilises a lithium-based ortho rearrangement of aryl phosphonates, readily prepared from the Atherton-Todd reaction of 1 with phenols. In both cases, the phosphinic acids were obtained in a final step by acid deprotection.

引用

页码：1145 / 1151

页数：7