(6R)-6-(SUBSTITUTED METHYL)PENICILLANIC ACID SULFONES - NEW POTENT BETA-LACTAMASE INHIBITORS

被引：7

作者：

ADAM, S

THEN, R

ANGEHRN, P

机构：

[1] F. Hoffmann-La Roche AG

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 04期

关键词：

D O I：

10.7164/antibiotics.46.641

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of (6R)-6-(substituted methyl)penicillanic acid sulfones has been prepared starting from the corresponding 6-(substituted methylene)penicillanates. The new sulfones 9a, 9b, 9c and 9d have been shown to be potent beta-lactamase inhibitors.

引用

页码：641 / 646

页数：6

共 13 条

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