SYNTHESIS OF RETIFEROL RAD(1) AND RAD(2), THE LEAD REPRESENTATIVES OF A NEW CLASS OF DES-CD ANALOGS OF CHOLECALCIFEROL

被引：24

作者：

KUTNER, A ^{[1
]}

ZHAO, H ^{[1
]}

FITAK, H ^{[1
]}

WILSON, SR ^{[1
]}

机构：

[1] NYU,DEPT CHEM,NEW YORK,NY 10003

来源：

BIOORGANIC CHEMISTRY | 1995年 / 23卷 / 01期

关键词：

D O I：

10.1006/bioo.1995.1002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The design and total convergent synthesis are described for the leading representatives of the new class of analogs of cholecalciferol with the CD-ring system replaced with a two-carbon aliphatic spacer. The leading representatives of C-21 retiferols (RAD(1) and RAD(2)) were obtained from a ring fragment derived from vitamin D and a chain fragment obtained from S-(-)-beta-citronellol. (C) 1995 Academic Press, Inc.

引用

页码：22 / 32

页数：11

共 39 条

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