SOMATIC HYPERMUTATION

被引：248

作者：

NEUBERGER, MS

MILSTEIN, C

机构：

[1] Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, Hills Road

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80010-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic features of the hypermutation, dissociated from the effects of antigenic selection.

引用

页码：248 / 254

页数：7

共 69 条

[61] WEBER JS, 1991, J IMMUNOL, V146, P3652
[62] WEBER JS, J IMMUNOL, V153, P3594
[63] RABBIT IGH SEQUENCES IN APPENDIX GERMINAL-CENTERS - VH DIVERSIFICATION BY GENE CONVERSION-LIKE AND HYPERMUTATION MECHANISMS
WEINSTEIN, PD
ANDERSON, AO
MAGE, RG
[J]. IMMUNITY, 1994, 1 (08) : 647 - 659
[64] ACCUMULATION OF SOMATIC MUTANTS IN THE B-CELL COMPARTMENT AFTER PRIMARY IMMUNIZATION WITH A T-CELL-DEPENDENT ANTIGEN
WEISS, U
ZOEBELEIN, R
RAJEWSKY, K
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (02) : 511 - 517
[65] WHAT LIMITS AFFINITY MATURATION OF ANTIBODIES IN XENOPUS - THE RATE OF SOMATIC MUTATION OR THE ABILITY TO SELECT MUTANTS
WILSON, M
HSU, E
MARCUZ, A
COURTET, M
DUPASQUIER, L
STEINBERG, C
[J]. EMBO JOURNAL, 1992, 11 (12) : 4337 - 4347
[66] PARALLEL EVOLUTION OF ANTIBODY VARIABLE REGIONS BY SOMATIC PROCESSES - CONSECUTIVE SHARED SOMATIC ALTERATIONS IN VH GENES EXPRESSED BY INDEPENDENTLY GENERATED HYBRIDOMAS APPARENTLY ACQUIRED BY POINT MUTATION AND SELECTION RATHER THAN BY GENE CONVERSION
WYSOCKI, LJ
GEFTER, ML
MARGOLIES, MN
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) : 315 - 323
[67] ANALYSIS OF SEQUENCE TRANSFERS RESEMBLING GENE CONVERSION IN A MOUSE ANTIBODY TRANSGENE
XU, B
SELSING, E
[J]. SCIENCE, 1994, 265 (5178) : 1590 - 1593
[68] LOCUS-SPECIFIC SOMATIC HYPERMUTATION IN GERMINAL CENTER T-CELLS
ZHENG, B
XUE, W
KELSOE, G
[J]. NATURE, 1994, 372 (6506) : 556 - 559
[69] DEVELOPMENT OF ANTIBODY DIVERSITY IN SINGLE GERMINAL-CENTERS - SELECTIVE EXPANSION OF HIGH-AFFINITY VARIANTS
ZIEGNER, M
STEINHAUSER, G
BEREK, C
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) : 2393 - 2400

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