SPECTRUM OF REACTIVITY WITH 3 MONOCLONAL-ANTIBODIES - MHM6(CD23), L30(CD24) AND UCHB1-IN B-CELL LEUKEMIAS

被引：6

作者：

BAIN, B ^{[1
]}

MORILLA, R ^{[1
]}

MONARD, S ^{[1
]}

KOKAI, Y ^{[1
]}

CATOVSKY, D ^{[1
]}

机构：

[1] ROYAL MARSDEN HOSP,ACAD DEPT HAEMATOL & CYTOGENET,FULHAM RD,LONDON SW3 6JJ,ENGLAND

来源：

LEUKEMIA & LYMPHOMA | 1990年 / 3卷 / 02期

关键词：

B-cell leukaemia; Leukaemia; Lymphoid leukaemia; Monoclonal antibody;

D O I：

10.3109/10428199009050982

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells from patients with a range of B-cell leukaemias have been investigated for reactivity with three monoclonal antibodies-MHM6 (CD23), L30 (CD24) and UCHB1. Cells in suspension were studied by indirect immunofluorescence and fixed cells in cytospin preparations by an indirect immunoperoxidase technique. Positive results with CD23 were obtained in two thirds of patients with chronic lymphocytic leukaemia in contrast to one quarter of cases of other mature B-lineage leukaemias and lymphomas; cells of acute lymphoblastic leukaemia gave negative results. L30 (CD24) had a wide spectrum of reactivity within the B-lineage with negative reactions being common only in hairy cell leukaemia and multiple myeloma/plasma cell leukaemia. UCHB1 was most frequently and most strongly positive in prolymphocytic leukaemia. Our observations suggest that these reagents, in particular L30 (CD24) and MHM6 (CD23), provide useful additional information in the differential diagnosis of B-lineage lymphoproliferative disorders. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：97 / 102

页数：6

共 12 条

[11]

Dorken B., Moldenhauer G., McMichael A.J., Phenotype analysis of the third international workshop B cell panel, Leucocyte typing III White cell differentiation antigens, pp. 369-373, (1987)

[12]

Jansen J., Le Bien T.W., Kersey J.H., The phenotype of the neoplastic cells of hairy cell leukemia studied with monoclonal antibodies, Blood, 59, pp. 609-614, (1982)

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