NOREPINEPHRINE DEPLETION REDUCES THE EFFECTS OF SOCIAL AND OLFACTORY EXPERIENCE

被引：8

作者：

CORNWELLJONES, CA

DECKER, MW

GIANULLI, T

WRIGHT, EL

MCGAUGH, JL

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

[2] UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY,IRVINE,CA 92717

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 25卷 / 05期

关键词：

6-Hydroxydopa; DSP-4; Frontal cortex; High affinity choline uptake; Hippocampus; Norepinephrine depletion; Odor preferences; Olfactory bulb; Olfactory cortex; Olfactory learning; Social experience;

D O I：

10.1016/0361-9230(90)90038-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Control juvenile rats adapted normally to a new home-cage bedding odor if they were caged with rats neonatally treated with 6-hydroxydopa, but not DSP-4. Neither social nor olfactory experience influenced preferences of NE-depleted rats. In some forebrain regions of controls caged with DSP-4 rats, monoamine concentrations were depressed and a metabolite elevated, suggesting the situation was stressful. DSP-4 treatment decreased the effect of footshock on hippocampal cholinergic activity, implying that NE depletion reduced sensitivity to stress. Thus, norepinephrine may modulate the biobehavioral effects of the postweaning olfactory and social environment. © 1990.

引用

页码：643 / 649

页数：7

共 44 条

[11] EARLY EXPERIENCE INFLUENCES ADULT RETENTION OF AVERSIVELY MOTIVATED TASKS IN NORMAL, BUT NOT DSP4-TREATED RATS [J].