ISOGRAVACRIDONCHLORINE - A POTENT AND DIRECT ACTING FRAMESHIFT MUTAGEN FROM THE ROOTS OF RUTA-GRAVEOLENS

被引：15

作者：

PAULINI, H

POPP, R

SCHIMMER, O

RATKA, O

RODER, E

机构：

[1] UNIV ERLANGEN NURNBERG,INST BOT & PHARMAZEUT BIOL,STAUDTSTR 5,W-8520 ERLANGEN,GERMANY

[2] FA MARTIN BAUER,W-8531 VESTENBERGSGREUTH,GERMANY

[3] UNIV BONN,INST PHARMAZEUT,W-5300 BONN,GERMANY

来源：

PLANTA MEDICA | 1991年 / 57卷 / 01期

关键词：

RUTA-GRAVEOLENS; FURANOACRIDONE ALKALOID; ISOGRAVACRIDONCHLORINE; FRAMESHIFT MUTAGEN; MUTAGENIC RESPONSE; SALMONELLA-TYPHIMURIUM;

D O I：

10.1055/s-2006-960019

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The furanoacridone alkaloid isogravacridonchlorine has been isolated from the roots of Ruta graveolens, the structure was elucidated by spectroscopic means. Its mutagenic activity and mode of action was characterized without as well as with metabolic activation using different Salmonella typhimurium strains.

引用

页码：59 / 61

页数：3

共 16 条

[11] MUTAGENICITY TESTING OF RUTACRIDONE EPOXIDE AND RUTACRIDONE, ALKALOIDS IN RUTA-GRAVEOLENS L, USING THE SALMONELLA MICROSOME ASSAY
PAULINI, H
SCHIMMER, O
[J]. MUTAGENESIS, 1989, 4 (01) : 45 - 50
[12] CHEMISTRY OF NATURAL SUBSTANCES .57. FURACRIDONE, 1-HYDROXY-3-METHOXY-N-METHYLACRIDONE AND ISOGRAVACRIDONCHLORINE FROM ROOTS OF RUTA-GRAVEOLENS
REISCH, J
ROZSA, Z
SZENDREI, K
NOVAK, I
MINKER, E
[J]. PHYTOCHEMISTRY, 1977, 16 (01) : 151 - 152
[13] REISCH J, 1972, SCI PHARM, V40, P161
[14] SVOBODA GH, 1966, LLOYD, V29, P206
[15] ALKALOIDS OF ACRONYCHIA BAUERI SCHOTT .2. ISOLATION OF ALKALOIDS AND A STUDY OF ANTITUMOR AND OTHER BIOLOGICAL PROPERTIES OF ACRONYCINE
SVOBODA, GH
POORE, GA
SIMPSON, PJ
BODER, GB
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (08) : 758 - &
[16] ANTIMICROBIAL SUBSTANCES IN CALLUS-CULTURES OF RUTA-GRAVEOLENS
WOLTERS, B
EILERT, U
[J]. PLANTA MEDICA, 1981, 43 (02) : 166 - 174

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