SYNTHESIS OF 7-FLUORO-2,4-METHYLENE-17,20-DIMETHYLPROSTACYCLINS - NOVEL STABLE PROSTACYCLIN ANALOGS AS POTENT ANTIANGINAL AGENTS

被引：22

作者：

MATSUMURA, Y

SHIMADA, T

NAKAYAMA, T

URUSHIHARA, M

ASAI, T

MORIZAWA, Y

YASUDA, A

机构：

[1] Research Center, Asahi Glass Co., Ltd., Kanagawa-ku, Yokohama, 221

来源：

TETRAHEDRON | 1995年 / 51卷 / 32期

关键词：

D O I：

10.1016/0040-4020(95)00468-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of new stable fluoroprostacyclins, 7-fluoro-2,4-methylene-17,20-dimethylprostacyclins (1, 2) with potent and long-lasting anti-anginal activities has been achieved. The cyclobutylene prostaglandin skeleton 10 was constructed efficiently according to three-component coupling reaction. Stereospecific fluorination of silyl ether 11 and subsequent cyclization of the fluoride 12 successfully provided the desired 7-fluoro-2,4-methylene-17,20-dimethylprostacyclin.

引用

页码：8771 / 8782

页数：12

共 55 条

[1]

[Anonymous], 1993, ORGANOFLUORINE COMPO

[2] SYNTHESIS OF NEW STABLE FLUOROPROSTACYCLIN ANALOGS WITH POTENT ANTIANGINAL ACTIVITY [J].