Position effect and related phenomena

被引:76
作者
Henikoff, Steven [1 ]
机构
[1] Fred Hutchinson Canc Res Unit, Howard Hughes Med Inst, Seattle, WA 98104 USA
关键词
PEV; position-effect variegation;
D O I
10.1016/S0959-437X(05)80114-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Position-effect variegation in Drosophila, the mosaic expression of genes juxtaposed to heterochromatin, remains an enigmatic long-range phenomenon. While the chromatin-conformation model has been challenged, compelling contrary evidence is lacking. Nevertheless, progress has been made in the genetic and molecular analysis of genes involved in the process of heterochromatin formation and in the characterization of genetic elements normally located in pericentric heterochromatin. In addition, telomeric position effect in yeast provides a new model system for the study of the quasi-stable inheritance of an inactivated state.
引用
收藏
页码:907 / 912
页数:6
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