METABOLISM AND DEGRADATION OF BETAMETHASONE 17-VALERATE IN HOMOGENIZED LIVING SKIN EQUIVALENT

被引：10

作者：

KUBOTA, K ^{[1
]}

ADEMOLA, J ^{[1
]}

MAIBACH, HI ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT DERMATOL,SAN FRANCISCO,CA 94143

来源：

DERMATOLOGY | 1994年 / 188卷 / 01期

关键词：

SKIN; METABOLISM; BETAMETHASONE; 17-VALERATE; CORTICOSTEROID;

D O I：

10.1159/000247077

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The metabolism of betamethasone 17-valerate was estimated using an artificial living skin equivalent (LSE). Betamethasone 17-valerate, betamethasone 21-valerate and betamethasone were measured by a normal-phase high-performance liquid chromatographic (HPLC) method. Betamethasone 17-valerate was added to the culture medium with or without LSE homogenate. Degradation profiles (%) of betamethasone 17-valerate remaining in the culture medium with skin homogenate did not differ from those without homogenate. However, the conversion of betamethasone 21-valerate to betamethasone was accelerated by skin homogenate, indicating that LSE has a sufficient level of esterase.

引用

页码：13 / 17

页数：5

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