HIGHER-ORDER NUCLEOPROTEIN COMPLEXES IN TRANSCRIPTION - ANALOGIES WITH SITE-SPECIFIC RECOMBINATION

被引：146

作者：

GROSSCHEDL, R ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, HOWARD HUGHES MED INST, DEPT BIOCHEM, SAN FRANCISCO, CA 94143 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 03期

关键词：

D O I：

10.1016/0955-0674(95)80091-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of transcription involves the assembly of multiprotein complexes at enhancers and promoters. interactions between adjacent and non-adjacent DNA-binding proteins can augment the specificity and stability of multicomponent nucleoprotein complexes. Recently, several proteins have been identified that can function as 'architectural' elements in the assembly of higher-order nucleoprotein structures reminiscent of those involved in site-specific recombination in prokaryotes.

引用

页码：362 / 370

页数：9

共 79 条

[41] Molina-Lopez, Govanted, Santero, Geometry of the process of transcription activation at the sigma 54-dependent nifH promoter of Klebsiella pneumoniae., J Biol Chem, 269, pp. 25419-25425, (1994)
[42] Giese, Kingsley, Kirshner, Grosschedl, Assembly and function of a TCRα enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein—protein interactions, Genes Dev, 9, pp. 995-1008, (1995)
[43] Travis, Amsterdam, Belanger, Grosschedl, LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor α enhancer function, Genes Dev, 5, pp. 880-894, (1991)
[44] Waterman, Fischer, Jones, A thymus-specific member of the HMG protein family regulates the human T cell receptor alpha enhancer, Genes Dev, 5, pp. 656-669, (1991)
[45] Carlson, Waterman, Jones, The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells., Genes & Development, 7, pp. 2418-2430, (1993)
[46] Giese, Grosschedl, LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites, EMBO J, 12, pp. 4667-4676, (1993)
[47] Ogawa, Maryuama, Kogoshima, Inuzuka, Lu, Satake, Shigesada, Ito, PEBP2/Pea2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene, Proc Natl Acad Sci USA, 90, pp. 6859-6863, (1993)
[48] Du, Thanos, Maniatis, Mechanisms of transcriptional synergism between distant virus-inducible enhancer elements, Cell, 74, pp. 887-898, (1993)
[49] Thanos, Du, Maniatis, The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex, Cold Spring Harbor Symp Quant Biol, 58, pp. 73-81, (1993)
[50] Du, Maniatis, The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms, Proc Natl Acad Sci USA, 91, pp. 11318-11322, (1994)

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