SEMINARS IN MEDICINE OF THE BETH-ISRAEL-HOSPITAL, BOSTON - THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND IMMUNE-MEDIATED INFLAMMATION

被引:1971
作者
CHROUSOS, GP
机构
[1] Developmental Endocrinology Branch, National Institute of Child Health, Human Development, National Institutes of Health, Bethesda, MD 20892, Bldg. 10
关键词
D O I
10.1056/NEJM199505183322008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye note that in rats exposed to stressors, the adrenal glands were enlarged, and the thymus and lymph nodes shrunken.1—3 Cortisone, the active principle of the adrenal glands, was isolated by Kendall and Reichstein in the late 1940s and shown to suppress immune organs. These scientists, along with Hench, received the Nobel Prize in Physiology and Medicine, after Hench and colleagues showed that cortisone could ameliorate rheumatoid arthritis.4,5 In recent. © 1995, Massachusetts Medical Society. All rights reserved.
引用
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页码:1351 / 1362
页数:12
相关论文
共 133 条
[61]  
JAATTELA M, 1991, ENDOCRINOLOGY, V128, P623
[62]   SUBSTANCE-P - MULTIFUNCTIONAL PEPTIDE IN THE HYPOTHALAMOPITUITARY SYSTEM [J].
JESSOP, DS ;
CHOWDREY, HS ;
LARSEN, PJ ;
LIGHTMAN, SL .
JOURNAL OF ENDOCRINOLOGY, 1992, 132 (03) :331-337
[63]  
KAM JC, 1993, J IMMUNOL, V151, P3460
[64]   AUTOCRINE OR PARACRINE INFLAMMATORY ACTIONS OF CORTICOTROPIN-RELEASING HORMONE INVIVO [J].
KARALIS, K ;
SANO, H ;
REDWINE, J ;
LISTWAK, S ;
WILDER, RL ;
CHROUSOS, GP .
SCIENCE, 1991, 254 (5030) :421-423
[65]   TRANSIENT CORTICOTROPIN DEFICIENCY IN CRITICAL ILLNESS [J].
KIDESS, AI ;
CAPLAN, RH ;
REYNERTSON, RH ;
WICKUS, GG ;
GOODNOUGH, DE .
MAYO CLINIC PROCEEDINGS, 1993, 68 (05) :435-441
[66]  
KIRKHAM BW, 1991, J RHEUMATOL, V18, P821
[67]  
KLEIN A, 1990, J RHEUMATOL, V17, P30
[68]  
KOWAKI G, 1994, NEUROIMMUNOMODULAT, V1, P127
[69]   CORTICOTROPIN-RELEASING FACTOR (OVINE) AND VASOPRESSIN EXERT A SYNERGISTIC EFFECT ON ADRENOCORTICOTROPIN RELEASE IN MAN [J].
LAMBERTS, SWJ ;
VERLEUN, T ;
OOSTEROM, R ;
DEJONG, F ;
HACKENG, WHL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (02) :298-303
[70]   SUBSTANCE-P INHIBITS THE RELEASE OF ANTERIOR-PITUITARY ADRENOCORTICOTROPIN VIA A CENTRAL MECHANISM INVOLVING CORTICOTROPIN-RELEASING FACTOR-CONTAINING NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS [J].
LARSEN, PJ ;
JESSOP, D ;
PATEL, H ;
LIGHTMAN, SL ;
CHOWDREY, HS .
JOURNAL OF NEUROENDOCRINOLOGY, 1993, 5 (01) :99-105